Vitis vinifera extract is a dietary supplement made by removing, drying, and pulverizing the bitter-tasting seeds of grapes. The extract is rich in antioxidants, including phenolic acids, anthocyanins, flavonoids, and oligomeric proanthocyanidin complexes (OPCs).

Vitis vinifera extract extractis one of the best-known sources of proanthocyanidins¹.
Due to its high antioxidant content, Vitis vinifera extract can help prevent disease and protect against oxidative stress, tissue damage, and inflammation².

Each Sunbio Collagen Peptides Beauty sachet contains 4875 mgs of Premium quality Australian derived Collagen Peptides, 100 mg of Vitamin C (Ascorbic Acid), 1200 mg of eqiv. Vitis vinifera extract and 2150 mcg of equiv. zinc

1.      Helps to reduce blood pressure
Several studies have been conducted to research the effects of Vitis vinifera extract on high blood pressure.
A review of 16 studies in 810 people with high blood pressure or an elevated risk of it found that taking 100–2,000 mg of Vitis vinifera extract daily significantly reduced systolic (the blood pressure when the heart is contracting) and diastolic blood pressure (diastolic pressure is specifically the minimum arterial pressure during relaxation and dilatation of the ventricles of the heart when the ventricles fill with blood), the top and bottom number, by an average of 6.08 mmHg and 2.8 mmHg, respectively.
The most promising results came from studies with lower doses of 100–800 mg daily for 8–16 weeks, rather than a single dose of 800 mg or more³.

2.      Can improve blood flow
Some studies have suggested that Vitis vinifera extract may improve blood flow.
During an 8-week study of 17 healthy postmenopausal women, taking 400 mg of Vitis vinifera extract had blood-thinning effects, potentially reducing the risk of blood clots⁴.
An additional study of 8 healthy young women assessed the effects of a single 400-mg dose of proanthocyanidin from Vitis vinifera extract immediately followed by 6 hours of sitting. Vitis vinifera extract was shown to reduce leg swelling and edema by 70%, compared with those not taking Vitis vinifera.
In the same study, 8 other healthy young women who took a daily 133-mg dose of proanthocyanidins from Vitis vinifera extract for 2 weeks experienced 40% less leg swelling after 6 hours of sitting⁵.
3.      Helps reduce oxidative stress
Oxidative stress can occur when there is an imbalance of free radicals and antioxidants in the body.
The body's cells produce free radicals during normal metabolic processes. However, cells also produce antioxidants that neutralize these free radicals. In general, the body is able to maintain a balance between antioxidants and free radicals.
Several factors contribute to oxidative stress and excess free radical production. These factors can include:
·         diet
·         lifestyle
·         certain conditions
·         environmental factors such as pollution and radiation
The body's natural immune response can also trigger oxidative stress temporarily. This type of oxidative stress causes mild inflammation that goes away after the immune system fights off an infection or repairs an injury.
Uncontrolled oxidative stress can accelerate the aging process and may contribute to the development of a number of conditions.
In a study in 87 people undergoing heart surgery found that taking 400 mg of Vitis vinifera extract the day before surgery significantly reduced oxidative stress. Therefore, Vitis vinifera extract is believed to have protected against further heart damage⁶.
4.      Helps improve collagen levels and bone strength
Increasing flavonoid consumption helps to improve collagen synthesis and bone formation. As a rich source of flavonoids, Vitis vinifera extract may therefore help increase the density and strength of your bones.
Animal studies have found that adding Vitis vinifera extract to either a low calcium, standard, or high calcium diet can increase bone density, mineral content, and bone strength^7,8.
Rheumatoid arthritis is an autoimmune condition that results in severe inflammation and the destruction of bone and joints.
Studies using animals have shown that Vitis vinifera extract may be suppressor of bone destruction in inflammatory autoimmune arthritis^9,10.
Vitis vinifera extract has also been shown to significantly reduced pain, bony spurs, and joint damage in osteoarthritic mice, improving collagen levels and reducing the loss of cartilage¹¹.
5.      Supports your brain as it ages
Scientists believe flavonoids’ combination of antioxidant and anti-inflammatory properties may delay or reduce the onset of neurodegenerative diseases like Alzheimer's disease¹².
Scientific studies using animals have found that Vitis vinifera extract may prevent memory loss, improve cognitive function and antioxidant levels of the brain, and reduce brain lesions and amyloid clusters A 12-week study in 111 healthy older adults found that taking 150 mg of Vitis vinifera extract daily improved mindfulness, language, and both immediate and delayed memory^13,14,15.
6.      Improves kidney function
Our kidneys are particularly susceptible to oxidative damage, which in many cases leads to irreversible long-term damage.
Scientific studies using animals have shown that Vitis vinifera extract may reduce kidney damage and improve function by reducing oxidative stress and inflammatory damage^16,17.
In one study, 23 people diagnosed with Chronic kidney disease were given 2 grams of Vitis vinifera extract daily for 6 months and then compared with a placebo group. Urinary protein decreased by 3% and kidney filtration improved by 9%¹⁸.

7.      Shown to inhibit infectious growth (Development of Infectious Diseases)
Vitis vinifera extract displays promising antibacterial and antifungal properties.
Studies have shown that Vitis vinifera extract inhibits the growth of foodborne bacteria including Campylobacter and E. coli, which are often responsible for severe food poisoning and abdominal upset^19,20.
In laboratory studies, Vitis vinifera extract has been shown to inhibit 43 strains of antibiotic-resistant Staphylococcus aureus bacteria²¹.
8.      May reduce cancer risk
The causes of cancer are complex; however, DNA damage is a central characteristic.
High intakes of antioxidants, such as flavonoids and proanthocyanidins, such as those found in Vitis vinifera extract are associated with a reduced risk of various cancers²².

The antioxidant activity of Vitis vinifera extract has shown potential to inhibit human breast, lung, gastric, oral squamous cell, liver, prostate, and pancreatic cell lines in laboratory settings^23,24,25,26.
In scientific studies using animals, Vitis vinifera extract has been shown to enhance the effect of different types of chemotherapy treatments^27,28,29.
Vitis vinifera extract appears to protect against oxidative stress and liver toxicity while targeting chemotherapy action on the cancerous cells³⁰. One review of 41 animal studies found that either GSE or proanthocyanidins reduced cancer-induced toxicity and damage in all but one of the studies³¹.
Please keep in mind that the anticancer and chemo-preventive potential of Vitis vinifera extract and the proanthocyanidins it contains may not be directly transferable to people with cancer.
9.      May protect your liver
Our liver plays an important role in detoxifying harmful substances that are introduced into our bodies through some medications, viral infections, pollution, alcohol, unhealthy diets, exposure to radiation, smoking, obesity, and exposure to pesticides or industrial chemicals.
Vitis vinifera extract is believed to have a protective effect on your liver, in in-vitro studies, Vitis vinifera extract reduced inflammation, recycled antioxidants, and protected against free radical damage during exposure to toxins^32,33.
The liver enzyme alanine aminotransferase (ALT) is a key indicator of liver toxicity, the rise of ALT levels is directly linked to damage that has been sustained by our livers.
In one scientific study, 15 people with non-alcoholic fatty liver disease and subsequent high ALT levels were given Vitis vinifera extract for 3 months. Liver enzymes were monitored monthly, and results were compared with a control group taking 2 grams of vitamin C per day. After 3 months, the Vitis vinifera extract group experienced a 46% reduction in ALT levels, while the vitamin C group showed little change in ALT levels³⁴.

10.  Enhances wound healing and appearance
Several scientific studies using animals have found Vitis vinifera extract can aid wound healing^35,36.
Scientific studies with humans show promise as well. In one such study, 35 healthy adults who had undergone minor surgery were given either a 2% Vitis vinifera extract cream or placebo. Those using the Vitis vinifera extract cream experienced full wound healing after 8 days, while the placebo group took 6 days longer to heal (14 days). These results are most likely a result of the high levels of proanthocyanidins in Vitis vinifera extract which triggers the release of growth factors in our skin³⁷.
In another 8-week study in 110 healthy young men, a 2% Vitis vinifera extract cream improved skin appearance, elasticity, and sebum content, which can help reduce the signs of aging³⁸.

Scientific Evidence

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